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Peg L Asparaginase injection
Product Code : 03
Brand Name : Peg L-Asparkay
Price And Quantity
- Minimum Order Quantity
- 1000 Pack
- Price
- 1 INR
Product Specifications
- Gender/Age Group
- Adult Women Suitable For All Ages
- Volume
- 3750 IU/5ml Milliliter (mL)
- Storage Instructions
- Store in Cool
Product Description
Warnings:
- Contraindications
- Hypersensitivity
- History of (with prior L-asparaginase treatment): pancreatitis; hemorrhagic events; serious thrombosis
Cautions:
- No more than 2ml should be administered at any one injection site
- Anaphylaxis or serious allergic reactions may occur, monitor patient for 1 hr after administration; discontinue with serious allergic reactions
- Glucose intolerance reported (irreversible in some cases); monitor serum glucose
- Hepatotoxicity and abnormal liver function, including elevations of AST (SGOT), ALT (SGPT), alkaline phosphatase, bilirubin (direct and indirect), and depression of serum albumin, and plasma fibrinogen may occur; monitor
- Discontinue if pancreatitis occurs; evaluate patients with abdominal pain for pancreatitis
- Serious thrombotic events, including sagittal sinus thrombosis reported; discontinue if this occurs
- Increased prothrombin time, increased PTT and hypofibrinogenemia may occur; monitor for coagulopathy
Pregnancy & Lactation
- Pregnancy Category: C
- Lactation: not known if excreted in breast milk
Pregnancy Categories
- A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
- B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
- C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
- D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
- X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
Pharmacology
- Mechanism of Action
- Modified version of L-asparaginase depletes asparagine, the aminoacid required for protein synthesis, and in turn kills leukemic cells
Pharmacokinetics
- Half-Life: 5-5.6 days
- Onset: Asparagine depleted within 4 days (IM)
- Duration: 21 days (IM); 2-4 weeks (IV in asparaginase naive adults)
- Vd: 1.5 L/m (IM in children); 2.4 L/m (IV in adults)
- Metabolism: Systemically
- Peak plasma time: 3-4 days (IM)
- Excretion: Urine (trace amounts)
Warnings:
- Refrigerate
- Do not use if cloudy or if precipitate is present
- Do not freeze
Specification
| Brand Name | Peg L-Asparkay |
| Best Before | 24 months from Manufacture date |
| Form Of Medicine | Injection |
| Grade | Medicine Grade |
| Storage | Store in cool and dry place |
| Packaging Size | 5 ml |
Trade Information
- Supply Ability
- Per Day
- Delivery Time
- 30-60 Days
- Sample Policy
- Sample costs shipping and taxes has to be paid by the buyer
- Main Export Market(s)
- Australia North America Eastern Europe Western Europe Middle East Central America South America Asia Africa
- Main Domestic Market
- All India
- Certifications
- USFDA
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